Ellenbroek SI, Collard JG (2007) Rho GTPases: functions and assoc

Ellenbroek SI, Collard JG (2007) Rho GTPases: functions and association with cancer. Clinical & Experimental Metastasis 24:657–672CrossRef 29. Jiang WG, Watkins G, Lane J et al (2003) Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clinical Cancer Res 9:6432–6440 30. Maloof P, Wang Q, Wang H et al (1999) Overexpression of retrovirally transduced basic FGF in

MCF-7 human breast cancer cells downregulates Bcl-2 and sensitizes cells to chemotherapy-induced apoptosis. Breast Cancer Res Treatment 56:153–167 31. Whitehead I, Kirk H, Tognon C et al (1995) Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C.

J Biol Chem 270:18388–18395CrossRefPubMed see more 32. Rodriguez PL, Sahay S, Olabisi OO et al (2007) ROCK I-mediated RSL-3 activation of NF-kappaB by RhoB. Cellular Signalling 19:2361–2369CrossRefPubMed 33. Zhong C, Kinch MS, Burridge K (1997) Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras transformed epithelial cells. Mol Biol Cell 8:2329–2344PubMed 34. Mitra SK, Schlaepfer DD (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Current Opinion in Cell Biology 18:516–23CrossRefPubMed 35. Cance WG, Harris JE, Iacocca MV et al (2000) Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: Barasertib research buy crotamiton correlation with preinvasive and invasive phenotypes. Clin Cancer Res 6:2417–2423PubMed 36. Lark AL, Livasy CA, Dressler L et al (2005) High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Modern Pathol 18:1289–1294CrossRef 37. Lin HJ, Hsieh FC, Song H et al (2005) Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. British J Cancer 93:1372–1381CrossRef 38. van Nimwegen MJ, Verkoeijen S, van Buren L et al (2005) Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. Cancer

Res 65:4698–4706CrossRefPubMed 39. Watermann DO, Gabriel B, Jager M et al (2005) Specific induction of pp125 focal adhesion kinase in human breast cancer. British J. Cancer 93:694–698CrossRef 40. Korah R, Das K, Lindy ME et al (2007) Co-ordinate loss of FGF-2 and laminin 5 expression during neoplastic progression of mammary duct epithelium. Human Pathology 38:154–160CrossRefPubMed 41. Borkhardt A, Bojesen S, Haas OA et al (2000) The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Proc Natl Acad Sci USA 97:9168–9173CrossRefPubMed 42. Hildebrand JD, Taylor JM, Parsons JT (1996) An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Molecular & Cellular Biology 16:3169–3178 43.

Comments are closed.