Methods: The focus group selleck compound met during the opening of a new CKD outpatient facility. It consisted of 12 patients with long-term experience of CKD,

dialysis and transplantation; they had been followed previously by the senior physician, who moderated the discussion. The discussion was tape-recorded and the results were summarized and approved by all participants.

Results: The group made 10 major suggestions: 1. Therapeutic continuity in all disease phases, from pre-dialysis to transplantation; 2. Possibility to choose the reference physician; 3. Strict integration with the nursing activities; 4. Organizational flexibility, to adapt to the needs of daily life; 5. To be “”fully”" taken care of, with organizational support for blood tests, imaging and consultations; 6. Need for time with the reference physician in critical phases of the disease; 7. Identification of a network of consultants, in keeping with the need for continuity of care; 8. Educational sessions; 9. Meetings for critical discussion of organizational performances; BEZ235 solubility dmso 10. As a setting: a home for the disease

and not a disease to take home.

Conclusion: Continuity of care and flexibility of organization, allowing time for education and discussion, are the quality requirements of our CKD patients.”
“A pair of novel tetrahydrobenzofuran-2,5-dione derivatives with a unique C-18 carbon skeleton, panamonon A (1) and B (2), was isolated from the leaves and twigs of Litsea panamonja (Nees) Hook. f. These new compounds contain an unprecedented C-18 carbon skeleton consisting of a characteristic tetrahydrobenzofuran-2,5(3H,6H)-dione ALK inhibitor core with a biosynthetically extended geranyl side chain, designated

as “”panamonane”". Their structures were elucidated by comprehensive spectroscopic analyses. A plausible biosynthetic pathway for 1 and 2 is discussed. The isolates were evaluated for cytotoxic activities against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.”
“In addition to known dibenzofuran derivatives such as (-)-usnic acid, (-)-isousnic acid and (-)-placodiolic acid, a Leprocaulon microscopicum acetone extract yielded a new compound, (+/-)-9-O-methylplacodiolic acid in a keto-enol equilibrium focused on the C-ring. Structures were established using mass spectrometry and combination of 1D and 2D NMR spectral data. C-13 assignments of placodiolic acid were revised. Tautomers of the (+/-)-9-O-methylplacodiolic acid were only separated by GC and a thorough fragmentation study confirmed the structural features. To complete the study, evaluation of antiproliferative effects on HT-29 human colorectal cancer cells showed moderate activity for (-)-usnic acid only. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.