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Gastrointest Liver Physiol 2000, 278:G438-G446.PubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions VRM performed all experiments with mRNA and protein expression and immunohistochemistry, and drafted the manuscript. XW analyzed urine samples for APAP and metabolites. PET developed method for APAP analysis by HPLC. ALS, LMA and VRM designed the experiment, and contributed to writing of manuscript. All authors read and approved the final manuscript.”
“Background Programmed cell death or apoptosis is an essential process for tissue homeostasis. Hepatocyte apoptosis is a common mechanism to many forms of liver disease. It has been recognized to contribute to the pathogenesis of alcoholic liver disease, nonalcoholic steatohepatitis, viral hepatitis, cholestatic liver disease, and ischemia/reperfusion injury [1–4]. Apoptosis can be triggered by Fas receptor mediated signaling as well as different stimuli that provoke cell stress.