The first of these established the neurodevelopmental view of schizophrenia, now widely accepted throughout the field. This model provides the logic of early intervention. The second tradition is far more empirical, and is based on increasing evidence that early treatment, initiated as close after onset of psychosis as possible, appears to improve outcome. It thus follows from these findings that treatment started before onset might be better still. The neurodelopmental model The currently

accepted view of schizophrenia holds that it is a gradually unfolding illness, one that Inhibitors,research,lifescience,medical has its roots in prenatal development. Though the evidence is indirect, it is believed that a genetic error of some kind (most likely in interaction with other biological and environmental factors) leads to subtle abnormalities in the evolving brain. The

resulting pathophysiology is not, in itself, schizophrenia, but rather a susceptibility or vulnerability to the disorder. Subtle vulnerability indicators can be detected Inhibitors,research,lifescience,medical throughout late childhood and early adolescence (eg, cognitive impairments, social difficulties), but the underlying disturbance begins to fulminate toward midadolescence, when clinical warning signs (ie, attenuated Inhibitors,research,lifescience,medical positive symptoms) become increasingly apparent. A number of models, differing from each other mainly in details, have been derived from this basic set of assumptions.2-10 The neurodevelopmental model is widely supported by both genetic high-risk prospective and birth cohort follow-back studies. In particular, Inhibitors,research,lifescience,medical genetic high-risk studies have implicated early cognitive and social skill deficits

in young at-risk offsprings of schizophrenic parents who later become ill.11-14 Follow-back studies, such as the British15,16 and Finnish birth cohorts,17 and the large population Swedish conscripts18,19 and Israeli Inhibitors,research,lifescience,medical army studies,7 have consistently reported a diversity of cognitive, social, and other developmental precursors to schizophrenia. The application of the neurodevelopmental view to prevention is threefold: first, this model depicts the clinical illness as a long-term, developmental process. As a result, intervention is viewed as being possible well before psychosis sets in, and thus, as having the potential Adenylyl cyclase to stop continued Fostamatinib datasheet progression to illness. Second, the proposed presence of a detectable, biological vulnerability provides the mechanism for early detection. In order to begin preventive treatment prior to illness onset, there must be a way to identify who is in need of intervention. Prodromal vulnerability indicators provide the means to identify those individuals who are at risk for illness. It should be noted that this represents a major advance, since risk has traditionally been a group construct, not definable on an individual level.