Whether this case was an idiosyncratic reaction or possibly a consequence of greater permeability in the blood brain barrier after craniospinal radiation with concurrent TMZ is unclear. Nevertheless, our situation report selleckchem Epigenetic inhibitor illustrates that TMZ alone may cause severe but potentially reversible neurotoxicity. TA 62. Security OF PROTRACTED Reduced DOSE TEMOZOLOMIDE FOR Individuals WITH MALIGNANT GLIOMA A. Ty, S. J. See, M. C. Wong, National Cancer Center and also the Nationwide Neuroscience Institute, Singapore The role of temozolomide in brain tumor therapy has been established. Nevertheless, the optimum dosing routine is undefined. Preclinical information recommend that a protracted dosing routine improves efficacy by exhaust ing AGT, consequently mind-boggling cellular repair systems. A latest clinical expe rience using a dose of 75 mg/m2 for 21/28 days reported extra lymphopenia but much less thrombocytopenia and reported much more infections and infection linked deaths in contrast with standard doses of 150 200 mg/m2 for that 5/28 day schedule.
This report particulars our encounter. From January 2003 to March 2006, eleven patients with histologi cally verified malignant gliomas obtained TMZ utilizing a reduced dose protracted routine. All patients selleckchem had been 18 years of age, had a Karnofsky Per formance Score 60, and had satisfactory hematologic, renal, and hepatic perform. Individuals acquired a median of 6 cycles of TMZ. The median dose was 63 mg/m2 for twenty days as well as a total of 107 cycles had been administered. Three individuals obtained concurrent radiation therapy and TMZ ahead of adjuvant TMZ. 4 patients had been heavily pretreated with 6 cycles of PCV just before second line TMZ chemotherapy. Adverse occasions had been graded in accordance to NCI Typical Toxicity Criteria, Version three. No grade III IV AEs or deaths linked to remedy were observed. Grade I II AEs complicated 13 cycles.
The most common grade I II AE was lymphopenia followed by fatigue, anemia, and constipation. In our group of patients, protracted very low dose TMZ was safe, with no grade III IV AEs or infection connected deaths. More information are required for clinicians to assess the frequency and risk of seri ous AEs in protracted TMZ regimens under evaluation. TA 63. PHASE I Research Final Security Benefits, CONVECTION ENHANCED DELIVERY OF CINTREDEKIN BESUDOTOX FOLLOWED BY RADIATION Therapy Without AND WITH TEMOZOLOMIDE IN NEWLY DIAGNOSED MALIGNANT GLIOMA M. A. Vogelbaum,1 J. H. Sampson,2 S. Kunwar,3 S. M. Chang,3 F. F. Lang,four M. Shaffrey,5 A. L. Asher,6 D. Croteau,seven K. Parker,seven J. L. Dul,7 J. W. Sherman,seven and R. K. Puri8, 1Cleveland Clinic Basis, Cleveland, OH, USA, 2Duke University Healthcare Center, Durham, NC, USA, 3University of California, San Francisco, CA, USA, 4The University of Texas M.