2006), suggesting that these areas are activated by a need for more information rather than the mere possibility of danger (see Shackman et al. 2009). In summary, these areas appear to be sensitive to unexpected cues signaling potential threat. In addition to areas overlapping with the attentional network proposed by Corbetta et al. (2008), anxious arousal was also associated

with habituation in paracingulate. This area responds when participants are threatened with painful physical stimulation (Jensen et al. 2003) or when presented with uncertainty during Inhibitors,research,lifescience,medical decision-making (Volz et al. 2005). Additionally, this area has exhibited hyperactivation when individuals with obsessive–compulsive disorder encounter stimuli related to compulsive checking (stimuli that engender uncertainty, Mataix-Cols et al. 2004). This research is consistent with a recent proposal that this region, along with nearby cingulate, is involved in adapting behavior in uncertain situations based on information Inhibitors,research,lifescience,medical gained from aversive outcomes (Shackman et al. 2011b). Present ON-01910 chemical structure findings are consistent with a proposed threat monitoring system that includes the right MTG/ITG

area and right MFG (Nitschke Inhibitors,research,lifescience,medical et al. 2000). This system is hypothesized to monitor for, and reorient toward, potential threat and to exert top-down control when threat is detected in order to respond effectively. Evidence suggests that hyperactivation of this system is associated with the attentional biases found in anxiety (Nitschke et al. 2000). Taken together with present findings, the research reviewed above indicates that anxious arousal is associated with immediate activation of a threat surveillance system, and that this activation diminishes over time. This suggests that anxious arousal is associated with initial identification of Inhibitors,research,lifescience,medical negative stimuli as salient and potentially threatening but that this perception weakens over time as stimuli become more familiar and predictable. Enhanced monitoring for, and reactivity to, negatively valenced information is adaptive in some situations. However, Inhibitors,research,lifescience,medical it may also lead to a chronic increase in distress in individuals with high levels of anxious arousal, because these individuals

consistently overidentify cues predictive of threat. In turn, this may foster irrational fears (e.g., specific phobias) and/or panic attacks, only because the likelihood of encountering threats is overestimated. However, the association between anxious arousal and habituation in attention-related brain regions indicates that individuals high in anxious arousal will be particularly amenable to exposure-based interventions, because habituation during exposure is predictive of recovery from anxiety disorders (Jaycox et al. 1998). Habituation associated with anxious apprehension Results revealed habituation in the response to negatively valenced stimuli in Broca’s area. Given the consistent association between Broca’s area and verbal rehearsal (Zatorre et al.