1%-29.9%) vs 33%). For both CD (22% vs 35%; p = 0.044) and UC (24% vs 53%; p = 0.024) continuing smokers after diagnosis were less often higher educated than quitters. SCH727965 Cell Cycle inhibitor Cessation plans (89%), passive smoking in childhood and present passive smoking were not different between CD and UC patients.

Conclusion: There are no differences in changes in smoking behaviour at and after diagnosis between CD and UC patients, suggesting a lack of knowledge in these patients about the link between their disease and smoking behaviour. However, CD patients seem less refractory to

smoking cessation than the general population. Therefore it is worthwhile putting energy in helping CD patients stop smoking. (C) 2009 European Crohn’s and Colitis Organisation. CA3 Published by Elsevier B.V. All rights reserved.”
“Objective: Systematic review and meta-analysis to investigate the association between maternal AGTR1 gene single nucleotide polymorphisms (SNPs) and preeclampsia (PE). Methods: A systematic literature search was performed using PubMed, EMBASE, Scopus, and HuGE Literature Finder databases. The review was conducted according to PRISMA guidelines. Summary odds ratios (ORs) for the allelic and genotypic contrasts were calculated and compared to indicate the most appropriate genetic

model for the polymorphism of interest. Among-study heterogeneity was assessed using the I-2 statistic and publication bias was evaluated visually using funnel plots. Results: Seven

maternal SNPs investigated with PE were found, but only AGTR1 + 1166A>C accumulated sufficient evidence for meta-analysis. Summary ORs calculated from eight studies (10 populations involving 845 PE cases and 1150 controls) did not reveal an association between the + 1166A>C polymorphism and PE (allelic OR = 1.19, 95% CI: 0.96-1.47). No evidence of publication bias and among-study heterogeneity was detected. Conclusions: meta-analysis findings did not buy NVP-LDE225 support AGTR1 + 1166A>C as a susceptibility locus for PE. Other AGTR1 SNPs require more study.”
“Purpose: A two-allele haplotype of TC (OCTN1 rs1050152 and OCTN2 -207G -> C) is associated with Crohn’s disease (CD). The association has been replicated in different populations, but also failed in some studies. The present study is to replicate the association of OCTN1 rs1050152 and examine another variant rs272879 with familial and sporadic inflammatory bowel disease (IBD) in a cohort from central Pennsylvania, USA.

Methods: The study samples (n=465) included 212 inflammatory bowel disease patients (CD = 115, UC = 97), including 103 familial (CD = 55, UC = 46) and 111 sporadic (CD = 60, UC = 51) IBD, 139 non-IBD family members from a familial IBD registry, and 114 unrelated healthy controls. A total of 12 OCTN1 variants within exonic sequences were examined.