3, P = 0.01), CMV infections (HR 1.6, P = 0.001), and AMR (HR 1.5, P = 0.002). The significantly worse graft survival in the alemtuzumab cohort may be due to the increased rates of AMR and infectious complications.”
“Compressive intradural metastases of the cauda equina are a rare site of metastatic spread in systemic cancer. So far, only few reports have been published with
conflicting statements concerning a surgical versus nonsurgical approach.
Five patients with symptomatic space-occupying intradural metastases of the cauda equina were analyzed retrospectively, focusing on the influence of surgical intervention on pain relief, neurological outcome and thus the patients’ quality of life.
At the time of diagnosis, all patients were in an advanced metastatic state. Surgical resection was the primary treatment in four patients and radiotherapy Cilengitide research buy in one. Despite infiltration of the cauda rootlets, gross total tumour resection could be achieved in two of the four patients treated surgically. Functional outcome
was beneficial in these patients with marked and immediate relief of pain and improvement of motor function even following incomplete tumour resection.
Surgical treatment of compressive intradural metastases of the cauda equina seems to be feasible with low operative risk and with the potential benefit of an immediate relief of pain and improvement in motor function and thus an increase in quality Selleck GW786034 of life.”
“Study Design. Data collected prospectively from the Prospective Pediatric Scoliosis Study (PPSS) were analyzed statistically to address the hypothesis that PD0332991 clinical trial covered specific aspects of treatment and its outcome.
Objective. To assess and contrast Scoliosis Research Society (SRS) outcome scores for patients assigned to one of three types of spinal instrumentation constructs.
The study hypothesis was that the instrumentation strategy that provides the best curve correction will be associated with the best SRS scores.
Summary of Background Data. Surgical treatment of scoliosis has evolved over time using implants and surgical techniques; however, quality of life indicators have not typically been analyzed to assess whether surgery and instrumentation will improve quality of life in pediatric patients.
Methods. Patients were assigned to one of three instrumentation groups depending on the type of construct used. The Scoliosis Research Society’s SRS-30 survey was used to measure patient outcomes comparing preoperative results to a 2-year follow-up.
Results. Changes in the SRS Pain, Activity, Appearance, Mental, Satisfaction, and SRS Total domains did not differ significantly among instrumentation groups for any time intervals. However, analysis of SRS Pain did show a significant change over time for all instrumentation patterns. The analysis of SRS Activity showed a significant change over time for all instrumentation patterns preoperatively to 2 years postoperatively.