(C) 2012 Elsevier B.V. All rights reserved.”
“The biliary leakage is a common and even lethal postoperative complication to the patients after hepatectomy. However, we found that the patients who selleck inhibitor underwent this lethal postoperative complication could potentially acquire a faster restoration of remnant liver volume comparing with

those without postoperative biliary leakage.\n\nWe surmise that inflammatory response induced by biliary leakage after partial hepatectomy may be the one of reasons for this phenomenon. Abnormal levels of TNF-alpha, IL-6, and STAT3 caused by biliary leakage may be a main reason for fast liver regeneration. On the other hand, we hypothesize that biliary leakage may promote liver regeneration by activating the immune system after partial hepatectomy.\n\nOur hypothesis might provide a novel therapeutic strategy for patients who underwent liver failure after partial hepatectomy. For instance, the exogenous infection or controlling biliary leakage may be reasonable and deserve further study. With the aid of animal model of postoperative biliary leakage or intra-abdominal bacterial infections, this hypothesis

could be partially or fully confirmed. (C) 2009 Elsevier Ltd. All rights reserved.”
“Diet and nutrition are estimated to explain as much as 30%-50% MEK162 mw of the worldwide incidence of colorectal cancer. In 2007, the World Cancer Research Fund (WCRF), in conjunction with the American Institute for Cancer Research (AICR), released the second expert report that summarizes the current PD173074 concentration scientific evidence linking diet to the prevention of cancer. This text provides an expert summary and level of evidence of the research relating diet/nutrients to factors that influence cancers of multiple

organs, including colon and rectum, with an important emphasis on global patterns. Specific examples include dietary fat, red and processed meat, and dairy, as well effects of nutrients such as calcium, folate, and vitamin D. Evidence is obtained from ongoing systematic literature reviews conducted by experts in both the United States and Europe. The expert panel applies standard practices to evaluate the strength and quality of individual studies to draw summary conclusions. In 2011, the report was updated to include findings from a series of meta-analyses published in 2010. To complement the WCRF/AICR report, the authors review the evidence favoring the role for diet and nutrition in the etiology of colorectal cancer. Specifically, they have integrated information gained from more recent meta-analyses and high-quality, prospective study findings, some of which have been included in the 2011 updated WCRF/AICR summary. (Nutr Clin Pract.