e., to maintain relevant concentration

thresholds in a local environment), but also behind their functional potential (as the basic scaffolding where transport and transduction mechanisms must be anchored). RG7420 clinical trial Actual biomembranes have implemented really sophisticated ways to control the matter and energy flow through the system, but thanks to highly specific protein devices whose appearance is difficult to understand without the long-term action of natural selection. However, given the high prebiotic plausibility of some aminoacids (Miller, 1953), it is quite reasonable to assume that short peptide chains were available from the very beginning. So it is necessary to investigate in which way simple oligopeptides (made of alanine, glycine, serine…) could be incorporated into selleck kinase inhibitor primitive compartments and change their properties,

for sure providing new operational or regulatory capacities to the system. Despite some remarkable attempts to work in this direction (Oliver and Deamer, 1994), little has been done experimentally, so far. Using our simulation model, we will show some results that support this find more hypothetical ‘lipid-peptide’ protocell scenario as a worth-exploring research avenue (Ruiz-Mirazo & Mavelli 2008). Chen I. A. and Szostak J.W., (2004). A Kinetic Study of the Growth of Fatty Acid Vesicles. Biophys. J. 87, 988. Chen I.A., Roberts R.W. and Szostak J.W., (2004). The Emergence of Competition Between Model Protocells. Science 305, 1474. Cheng Z. and Luisi P.L., (2003). Coexistence and mutual competition of vesicles with different size distributions. J. Phys. Chem. B 107, 10940. Hargreaves, WR. Deamer, DW. (1978). Monoalkylliposomes. Biochemistry 17, 3759–3768. Mavelli, F., Lerario, M. and Ruiz-Mirazo, K. (forthcoming) ‘ENVIRONMENT’: a stochastic simulation platform to study protocell dynamics. BIOCOMP’08 Proceedings. Mavelli, F. and Ruiz-Mirazo, K. (2007a). Stochastic simulations of minimal self-reproducing cellular systems. Phil. Trans. R. Soc. B 362, 1789. Mavelli, F. and Ruiz-Mirazo K., (2007b). Stochastic Simulation of fatty acid protocell models. In:

Sergey M. Bezrukov, editor, Proteases inhibitor Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems. Bellingham, Washington: SPIE (United States), 6602, 1B1. Miller, S. L. (1953). A production of amino acids under possible primitive Earth conditions. Science 117, 528–529. Oliver A.E. & Deamer D.W. (1994). Alpha-helical hydrophobic polypeptides form proton-selective channels in lipid bilayers. Biophys J. 66(5): 1364–1379. Pozzi G., Birault V., Werner B., Dannenmuller O., Nakatani Y., Ourisson G. and Terakawa S., (1996). Single-chain polyprenyl phosphates form “primitive” membranes. Angew. Chem. Int. Ed. Engl., 35: 177–179. Rasi, S., Mavelli, F. and Luisi, P.L. (2004). Matrix effect in oleate micelles-vesicles transformation.