First-in-man results with this device were very promising. European clinical trials for both of these new products will start in 2012. The PARTNER II Trial, which is studying the Edwards SAPIEN XT valve in an expanded patient population, is currently underway in the United States. Enrollment in Cohort B of this trial was completed in January 2012. Enrollment also began in PARTNER II Cohort A, which is studying patients with a lower risk profile than those who were enrolled in The PARTNER Trial. Medtronic Engager™ Aortic Valve The Medtronic Engager aortic valve prosthesis has shown promising

first results in a registered trial and Inhibitors,research,lifescience,medical will be launched soon.13 Designed for transapical use, this valve has a trileaflet bovine pericardial tissue design mounted on a self-expanding nitinol stent frame that is covered with a polyester skirt to prevent periprosthetic AR (Figure 5). In check details addition, this prosthesis has a low device implant height to ensure clearance from coronary ostia and positioning Inhibitors,research,lifescience,medical arms that are anchored over the native leaflets to enable optimal alignment of the valve in the native annulus and to Inhibitors,research,lifescience,medical prevent periprosthetic AR. Figure 5 Medtronic Engager™ Transcatheter Aortic ValveCourtesy of Medtronic, Inc., Minneapolis, Minnesota. JenaValve™ Aortic Valve The JenaValve (JenaValve, Munich, Germany) consists of a porcine root valve sewn

onto a Nitinol self-expanding stent (Figure 6). The JenaValve

is available in three sizes (23 mm, 25 mm, and 27 mm) and covers aortic valve annuli from 21 mm to 27 mm. The Nitinol stent has three self-expanding feelers that allow the prosthesis to be accurately Inhibitors,research,lifescience,medical positioned in the aorta. Furthermore, before being sewn onto the stent, the lower part of the valve is fitted with an outer porcine pericardial skirt to minimize paravalvular leakage. The JenaValve system is fully repositionable and retrievable and is delivered transapically via a 32-Fr introducer sheath. After the feelers have been placed in the correct position in the sinuses of the native Inhibitors,research,lifescience,medical valve, the lower part of the prosthesis is released. below The Nitinol stent self-expands to anchor in the native annulus, and the new valve immediately starts to function. During release, the native valve leaflets are clipped between the feelers and the base of the prosthesis. This JenaClip mechanism firmly anchors the JenaValve in the correct anatomical position and provides active fixation and resistance to migration. The delivery system can then be safely retracted. Results in 67 patients have been very promising, with a 30-day survival rate of 92%.14 JenaValve Technology received CE Mark approval for their device at the end of September 2011. Figure 6 JenaValve aortic valve prosthesis for transapical useCourtesy of JenaValve™ Technology, Inc., Munich, Germany.