Here, we report a novel infection-enhancing epitope on dengue
prM, the findings from our study may have significant implications for future vaccine design and facilitate understanding the pathogenesis of DENV infection. Conclusions We mapped the epitope of 4D10 to amino acid residues 14 to 18 of DENV1-4 prM using a phage-displayed peptide library and comprehensive bioinformatic analysis. Then, we found that this epitope was infection-enhancing. These findings may provide important information for the understanding of the pathogenesis of DENV infection at epitope level and contribute to the development of dengue vaccine. Acknowledgements We are grateful to Dr. Yuan Chen for critical reading of the manuscript and for many helpful suggestions. We thank Haizhu district center for disease control and prevention of Guangzhou for providing human serum samples.
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