However, viral DNA remains detectable in PLs for at least 3

weeks postinfection, past the point of viral clearance observed in the kidneys. This suggests that although PLs are actively involved in anti-FV3 immune responses, some of these cells can be permissive and harbor quiescent, asymptomatic FV3.”
“With every movement of the eye the visual field is drastically displaced in space However our visual experience is stable rather than constantly jittering with every saccade One neural mechanism thought to underlie such spatial constancy across saccades is predictive remapping in Veliparib order which visual receptive fields remap to non-classical future locations in anticipation of a forthcoming saccade We investigated mechanisms of predictive remapping in humans using a cross-hemispheric remapping paradigm EEG was recorded while subjects performed a VX-809 datasheet task requiring leftward and rightward horizontal saccades in the presence of salient peripheral stimuli Saccades caused the peripheral stimuli to either shift between the two visual hemifields (Cross condition) necessitating remapping between cerebral hemispheres or to shift within a single visual hemifield (Within condition)

requiring remapping only within a single hemisphere Saccade-locked event-related potentials were calculated for each of these conditions A baseline saccade-only condition was subtracted from experimental conditions to isolate remapping activity from activity related to saccade check details planning and generation In a presaccadic time window difference waveforms were consistent with predictive remapping exhibiting an ipsilateral positivity in the Cross condition and a contralateral positivity in the Within condition

This result is consistent with the occurrence of remapping in advance of a saccade A similar pattern was also apparent in an intrasaccadic time window suggesting that predictive remapping persists during saccadic execution Examination of postsaccadic visual responses revealed that hemispheric distributions of Cross and Within conditions matched the distribution of the corresponding presaccadic remapping response suggesting that the pressacadic response indeed reflects a shift of visual representations to match that of postsaccadic space (C) 2010 Elsevier Ltd All rights reserved”
“The cytoplasmic domain of glycoprotein B (gB) from herpes simplex virus type 1 (HSV-1) is an important regulator of membrane fusion. C-terminal truncations of the cytoplasmic domain lead to either hyperfusion or fusion-null phenotypes. Currently, neither the structure of the cytoplasmic domain nor its mechanism of fusion regulation is known. Here we show, for the first time, that the full-length cytoplasmic domain of HSV-1 gB associates stably with lipid membranes, preferentially binding to membranes containing anionic head groups. This interaction involves a large increase in helical content.