In C1, 71% of the grid-sectors in the LH showed visual activation. Similar to the RH, the sectors that were not MK-8776 nmr visually responsive were located in anterior and ventral sectors of the grid, likely due to the parafoveal location of the object stimuli. In SM, 79% of the grid in the LH showed activation, and most of
the sectors that were not responsive to visual stimulation were located outside LOC. A comparison of the number of activated sectors during presentations of all types of objects combined as well as during presentations of individual types of objects between the group and SM, as well as SM and C1, revealed no significant differences (p > 0.05; Table S2). In the control group, 77% ± 10% of the grid in the LH showed object-related responses. In C1, 70% of
the grid in the LH showed object-related responses, which was similar to the group (p > 0.05). In SM, 30% of the grid in the LH showed object-related responses. Similar to healthy subjects, sectors that were not responsive were located in anterior and ventral sectors of the Cobimetinib grid, and thus outside LOC. The number of activated sectors was significantly reduced in SM as compared to the control group and C1 (p < 0.05). Importantly, a comparison of the number of activated sectors showing object-related responses in the LH and RH revealed no inter-hemispheric differences in the group, SM, or C1 (p > 0.05). In the group, 70% ± 12%, and in C1, 61% of the grid showed object-selective responses. Dramatically, in SM, only 4% of the grid in the LH responded in an object-selective manner. Both sectors were located in LOC and hence in posterior and dorsal sectors of the grid. The comparison between the group and SM, and C1 and SM, showed a significant reduction in SM in the number of object-selective sectors (p < 0.01). The interhemispheric comparison of object-selective responses revealed no significant differences among the group, SM, or C1 (p > 0.05). It is important to note that the object-selective responses as revealed by the AIs applied to all stimulus
types, with reduced object-selective responses in SM compared to the group GPX6 or to C1 (p < 0.05). Interhemispheric comparisons revealed similar responses in both hemispheres for the group, SM, and C1 (p > 0.05). Intriguingly, SM showed reduced object-selectivity in the structurally intact LH regions of cortex that were mirror-symmetric to the RH lesion site (2D objects, 4% versus 12%; 3D objects, 6% versus 18%; line drawings, 4% versus 10%; 2D-size, 6% versus 16%; 3D-viewpoint, 2% versus 8%). To quantify the interhemispheric response profiles, the magnitude of responses to visual stimulation was examined. As a first step, the strength of mean signal changes of each grid sector was determined.