Moreover, it could be also useful to compare the thermal response of different kinds of nanoparticles under different working conditions as, for example, concentration, optical density, dispersion media, or sample holder. Therefore, the photothermal transduction efficiency is needed to determine the optimal conditions depending on each considered case. To summarize, we can say that, from a series of input data to the

system, as the power of irradiation Autophagy inhibitor clinical trial and the optical density of the used nanoparticles, it is possible to calculate the photothermal transduction efficiency of these particles using the thermal parameters of the system and the temperature variation of the samples. Therefore, it is possible to determine, for any kind of gold nanoparticles (or other noble metals) with their peak of OICR-9429 price absorption syntonized with the wavelength of irradiation, the percentage of the optical power that interacts

(absorption + scattering) with the sample that really becomes in a temperature increasing. The higher the value of this parameter, the higher the efficiency of the designed optical hyperthermia treatment, and so, if we know the value of this parameter previously, we could select those nanoparticles that allow us to obtain better results in the designed therapy. Acknowledgements The authors gratefully acknowledge the support of the Biomedical Research Networking Oxymatrine Center. References 1. Letfullin RR, George TF: Plasmonic nanomaterials in nanomedicine. Selleck LY2603618 In Springer Handbook of Nanomaterials. Edited by: Vajtai R. Berlin: Springer; 2013:1063–1097.CrossRef 2. Letfullin RR, Iversen CB, George TF: Modeling nanophotothermal therapy: kinetics of thermal ablation of healthy and cancerous cell organelles and gold nanoparticles. Nanomedicine 2011, 7:137–145. 10.1016/j.nano.2010.06.011CrossRef 3. Letfullin RR, George TF: Nanomaterials in nanomedicine. In Computational Studies

of New Materials II: From Ultrafast Processes and Nanostructures to Optoelectronics, Energy Storage and Nanomedicine. Edited by: George TF, Jelski D, Letfullin RR, Zhang GP. Singapore: World Scientific; 2011:103–129.CrossRef 4. Ni W, Kou X, Yang Z, Wang J: Tailoring longitudinal surface plasmon wavelengths, scattering and absorption cross sections of gold nanorods. ACS Nano 2008, 2:677–686. 10.1021/nn7003603CrossRef 5. von Maltzahn G, Park JH, Agrawal A, Bandaru NK, Das SK, Sailor MJ, Bhatia SN: Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Res 2009, 69:3892–3900. 10.1158/0008-5472.CAN-08-4242CrossRef 6. Peng CA, Wang CH: Anti-neuroblastoma activity of gold nanorods bound with GD2 monoclonal antibody under near-infrared laser irradiation. Cancers (Basel) 2011, 3:227–240. 10.3390/cancers3010227CrossRef 7.