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analyses. CAS and JJvA carried out the murine infection studies. MC performed Bcl-w the growth curve experiments. EMH and HYO participated in experimental design and bioinformatics analyses. KR and JJvA conceived the study, participated in its design and coordination and drafted the manuscript. SGS, KAK and CS contributed to experimental design and analysis. All authors read, contributed to and approved the final manuscript.”
“Background Selleckchem Ferroptosis inhibitor Borrelia burgdorferi, the spirochetal agent of Lyme disease, possesses a dual-membraned (diderm) architecture, which is composed of a peptidoglycan layer associated with the inner membrane (IM) and an outer membrane (OM) [1, 2]. In Gram-negative bacteria, cytoplasmic precursor outer membrane proteins (OMPs) are synthesized with an amino-terminal signal peptide sequence, which typically targets a protein for Sec-mediated translocation.