Respiratory parameters and proinflammatory markers were measured as outcome.
There was no difference in PaO(2) between groups. PaCO(2) (P < 0.01) and ventilatory rate (P < 0.01) were higher at 1.5 h OLV and at the end point in the PVS group. Peak inflating pressure (PIP) and pulmonary resistance were higher (P < 0.05) in the control group at 1.5 h OLV. tumor necrosis factor-alpha (P < 0.04) and IL-8 were less (P < 0.001) in the plasma from the PVS group, while IL-6 and IL-8 were less (P < 0.04) in the
lung tissue from ventilated lungs in the PVS group.
Based on this model, PVS decreases inflammatory injury both systemically AZD8186 ic50 and in the lung tissue with no adverse
effect on oxygenation, ventilation, or lung function.”
“BACKGROUND: Enantioselective bioreduction of acetophenone to S-(-)-1-phenylethanol by Saccharomyces cerevisiae under non-growth conditions is inhibited by the product created. This study investigated the possibility of intensification and mathematical simulation of 1-phenylethanol production using periodic product removal carried out by membrane extraction in a hollow fiber membrane module. RESULTS: The highest reaction rate was observed at the beginning of the biotransformation. With increased product concentration in the reaction medium, the reaction rate gradually decreased by about 50% after 20 h of biotransformation. The low concentration of product maintained in the BYL719 reaction medium using membrane extraction had positive
PFTα influence on the 1-phenylethanol production with a high yield (96%) and mean reaction rate of 0.226 mg h-1g-1, 35% higher than biotransformation without product removal. The equilibrium change and membrane fouling caused by biomass were not significant. It was possible to mathematically simulate the whole course of the extractive biotransformation with good agreement with experimental data. CONCLUSION: Bioreductive production of 1-phenylethanol is more effective when using periodic membrane extraction of the product from the fermentation broth, which gives higher reaction rate, higher yield and simpler downstream process than biotransformation without product removal. Copyright (c) 2012 Society of Chemical Industry”
“Objective: The etiology of jaundice in otherwise healthy breastfed newborns that can present as early-onset exaggerated physiologic jaundice, or late breast milk jaundice (BMJ), is not yet entirely understood. This study tested the hypothesis that molecular marker for Gilbert’s syndrome (GS), UGT1A1 TATA-box polymorphism, is associated with this disorders.
Methods: We have investigated the UGT1A1 polymorphism frequency and its relation to severity of hyperbilirubinemia and jaundice duration among 220 exclusively breastfed term newborns; 57 of them with non-physiologic hyperbilirubinemia (NH), and 163 with BMJ, and in 187 healthy controls.