stirring rate 300 rpm, extraction temperature 70 degrees C, liqui

stirring rate 300 rpm, extraction temperature 70 degrees C, liquid to solid ratio 5.2:1 and extraction time 52 min. The physicochemical properties were determined to evaluate the quality of seed oil. The chemical composition of extracted seed oil was analyzed by GC-MS. This novel extraction technique provided high throughput and high quality oil. (C) 2012 Elsevier B.V. All rights reserved.”
“Background and objective: Recently, angiopoietin-2 (Ang-2) was identified

as a ligand of the endothelial receptor tyrosine kinase, Tie-2. Ang-2 is an angiopoietin-1 antagonist that plays a role in vascular destabilization and remodelling, which may increase in some diseases. However, serumAng-2 levels have not been evaluated in patients YAP-TEAD Inhibitor 1 with COPD. In this study, we examined Navitoclax price serum Ang-2 concentrations in patients experiencing COPD exacerbations and in patients with stable COPD.

Methods: Serum samples were obtained from 49 patients experiencing COPD exacerbations, 22 patients with stable COPD and 18 healthy control subjects. Serum Ang-2 concentrations were measured by ELISA.


Serum Ang-2 concentrations were significantly higher in patients with acute exacerbations of COPD than in those with stable COPD or control subjects, and were significantly positively correlated with serum CRP levels but inversely correlated with PaO(2) in patients with exacerbations. In addition, Ang-2 levels decreased significantly after clinical recovery from the acute see more exacerbation.

Conclusions: Serum Ang-2 levels are significantly elevated during acute exacerbations of COPD, as compared with stable COPD.”
“Hypertension is the most-prevalent modifiable risk factor for cardiovascular morbidity and mortality worldwide. Hypertension is highly prevalent among older adults (>= 65 years), and aging of the population will substantially increase the prevalence of this condition. Age-related endothelial dysfunction and increased arterial stiffness contribute to the increased prevalence of hypertension, particularly systolic hypertension, among the elderly.

The incidence of some forms of secondary hypertension also increases with age, mainly owing to the use of drugs (especially NSAIDs that have pressor effects) and the presence of chronic kidney disease, obstructive sleep apnea, and renal artery stenosis. Guidelines differ in thresholds and goals for antihypertensive drug therapy in the elderly because of a paucity of high-level evidence from randomized controlled trials and inconsistencies in the definition of ‘elderly’. Medical treatment of hypertension reduces cardiovascular morbidity and mortality in the elderly, and all guidelines recommend lifestyle modifications and medical treatment for elderly patients whose blood pressure exceeds prescribed thresholds and who are at moderate or high cardiovascular disease risk.

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