Symptom score improvements seemed to be sufficient and durable (Figure 11). The company has initiated an international, multicenter, randomized, sham-controlled (randomization 3:1 active vs sham) trial that has just started in the United States. The data from this trial will determine whether the technology will be submitted for approval to the FDA.101 Figure 11 International Inhibitors,research,lifescience,medical Prostate Symptom Score (IPSS), benign prostatic hyperplasia (BPH) II, and quality of life (QoL) measures demonstrate sustained reduction through 3 years of follow-up.

(P < .05 for all displayed values). Reproduced with permission ... Overall, the 2011 AUA Annual Meeting in Washington, DC, provided an opportunity to learn more about the basic science, Inhibitors,research,lifescience,medical epidemiology, and natural history of LUTS and BPH as well as a host of medical and device treatments with their respective outcomes. In addition, LUTS and BPH are also conditions often examined in the sessions on cost-effectiveness and practice patterns. [Claus G. Roehrborn, MD, FACS]
Injury to the lower urinary tract is relatively uncommon in the setting of blunt trauma. However, it is particularly susceptible to those forces that produce sufficient energy to

cause pelvic ring disruption. As a result, at least 85% of bladder ruptures are associated with pelvic fracture.1,2 Urethral disruption has been reported in 3.5% to 28.8% of patients with pelvic fractures, almost exclusively in Inhibitors,research,lifescience,medical men. In Inhibitors,research,lifescience,medical Victoria, lower urinary tract injuries occurred in 1.5% of major trauma patients in 2009 (data from the Victorian State Trauma Outcomes Registry). It is well recognized that prompt recognition and early management of these urological injuries can significantly reduce morbidity and mortality. Difficulties arise in the severely injured multitrauma patient when lifesaving measures or damage-control surgery may delay the diagnosis and treatment of lower urinary tract injuries. As management strategies have become more conservative, particular attention has been given to defining patients

who would benefit most from intervention. This article describes the management of lower urinary tract Inhibitors,research,lifescience,medical injuries as practiced at Australia’s busiest below trauma center. Bladder The bladder is a muscular organ which, when empty, lies protected by the anterior bony pelvis. It is located extraperitoneally in the adult with peritoneum covering the superior surface. The dome is the most mobile and weakest part of the bladder, leaving it susceptible to rupture when the bladder is full. Associated injuries in bladder trauma are common and include pelvic fractures (93%–97%), long bone injuries (50%–53%), and central nervous system (28%–31%) and thoracic injuries (28%–31%).3,4 The mortality related to bladder trauma can be as high as 34% and is largely a consequence of associated injuries rather than bladder perforation find more itself. Mechanism Bladder perforation is seen most commonly in blunt trauma and infrequently as a result of penetrating injuries.