T. Zahrt for plasmid pFNLTP6 gro-gfp. This study was supported by U.S. Public Health Service grant POAI55637. References 1. Radtke AL, O’Riordan MX: Intracellular selleck compound innate resistance to bacterial pathogens. Cell Microbiol 2006, 8:1720–1729.PubMedCrossRef 2. Paradkar P, De Domenico I, Durchfort N, Zohn
I, Kaplan J, Ward DM: Iron-depletion limits intracellular bacterial growth in macrophages. Blood 2008, 112:866–874.PubMedCrossRef 3. Collins HL: The role of iron in infections with intracellular bacteria. Immunol Lett 2003, 85:193–195.PubMedCrossRef 4. Chlosta S, Fishman DS, Harrington L, Johnson EE, Knutson MD, Wessling-Resnick M, Cherayil BJ: The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica. Infect Immun 2006, 74:3065–3067.PubMedCrossRef 5. Bullen JJ, Rogers HJ, Spalding PB, Ward CG: Natural resistance, iron and infection: a challenge for clinical medicine. J Med Microbiol 2006,
55:251–258.PubMedCrossRef 6. Schaible UE, Kaufmann SH: Iron and microbial infection. Nat Rev Microbiol 2004, 2:946–953.PubMedCrossRef 7. Kehrer JP: The Haber-Weiss reaction and mechanisms of toxicity. Toxicology 2000, 149:43–50.PubMedCrossRef 8. Theurl I, Fritsche G, Ludwiczek S, Garimorth K, Bellmann-Weiler R, Weiss G: The macrophage: a cellular factory at the interphase between iron and immunity for the control of infections. Biometals 2005, 18:359–367.PubMedCrossRef 9. Howe D, Mallavia LP: Coxiella burnetii infection increases transferrin receptors
on J774A. 1 cells. Infect Immun 1999, 67:3236–3241.PubMed 10. Barnewall RE, Ohashi N, Rikihisa Ureohydrolase Y: Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with PD-0332991 solubility dmso transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. Infect Immun 1999, 67:2258–2265.PubMed 11. Clemens DL, Horwitz MA: The Mycobacterium tuberculosis phagosome interacts with early endosomes and is accessible to exogenously administered transferrin. J Exp Med 1996, 184:1349–1355.PubMedCrossRef 12. Steele-Mortimer O: The Salmonella-containing vacuole-Moving with the times. Curr Opin Microbiol 2008, 11:38–45.PubMedCrossRef 13. Clemens DL, Lee BY, Horwitz MA: Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages. Infect Immun 2004, 72:3204–3217.PubMedCrossRef 14. Deng K, Blick RJ, Liu W, Hansen EJ: Identification of Francisella tularensis genes affected by iron limitation. Infect Immun 2006, 74:4224–4236.PubMedCrossRef 15. Sullivan JT, Jeffery EF, Shannon JD, Ramakrishnan G: Characterization of the siderophore of Francisella tularensis and role of fslA in siderophore production. J Bacteriol 2006, 188:3785–3795.PubMedCrossRef 16. Su J, Yang J, Zhao D, Kawula TH, Banas JA, Zhang JR: Genome-wide identification of Francisella tularensis virulence determinants. Infect Immun 2007, 75:3089–3101.PubMedCrossRef 17.