Table 6Comparison of cutoff value, sensitivity, specificity, AUC*, and P values between OI and physiological severity scores.3.5. Relevance of Day 3 OI Stratified Values and Survival TimeTo illustrate the correlation between Tipifarnib oxygenation index and survival time, we stratified day 3 oxygenation index into 4 groups (0

Weaning OutcomesTable 7 shows baseline characteristics of patients successfully weaned from ventilator and those who failed to wean. Table 8 shows respiratory and ventilator parameters of these patients on day 1 and day 3. Of the 62 survivors, 46 patients (74%) successfully weaned from ventilator, 16 patients (26%) failed to wean. Presence of preexisting cerebrovascular accident (CVA) (P < 0.001) and cancer history (P = 0.042) were associated with weaning failure. Although both groups had improving OI from day 1 to day 3, there was significant difference in the magnitude of OI change. The group who failed to wean had less OI improvement than the weaning success group (?1.06 versus ?3.32, P = 0.008). However, there were no difference between the 2 groups in age (P = 0.08), gender (P = 0.

86), all other background illnesses except CVA and cancer history, and all other ventilatory and respiratory parameters except OI change.Table 7Characteristics of patients with different weaning outcomes: bivariate analysis#.Table 8Day 1 and day 3 respiratory and ventilator parameters of patients with different weaning outcomes#.3.7. Predictors of Weaning FailureUnivariate analysis identified history of CVA as the potential risk factor for weaning failure (AOR=12.33, 95% CI 3.21�C47.38, P < 0.001). OI change from day 1 to day 3 was also included in the multivariate analysis, since its association with weaning outcome is physiologically plausible and its P value is less than 0.1 in univariate logistic regression (AOR=0.792, 95% CI 0.62�C1.02, P = 0.069). The results of multivariate Cilengitide analysis were shown in Table 9. Only history of CVA was identified as independent predictor of weaning failure (AOR=10.16, 95% CI 2.37�C43.58, P = 0.002).Table 9Multivariate analysis of predictors of weaning failure in patients with severe acute respiratory failure.4. DiscussionThis study has several findings.