These adverse reactions are the reason why the dosage of TCAs has to be achieved progressively, over several days. Because of these adverse reactions, the patient may have to stay off work for longer periods of time with TCAs than with recent ADs. These drugs may also induce weight gain of over 10 kg in several weeks and impaired sexual function, which are a source of distress to patients. A 1 tough the adverse reactions of recent ADs may occasionally be experienced by patients as disagreeable and troublesome, they Inhibitors,research,lifescience,medical are less frequent and less severe than those of the TCAs. This advantage is borne out by some patients treated with recent ADs who report no medication-related

unwanted effects, a degree of patient satisfaction paralleled only rarely by the TCAs. Further

confirmation comes from clinical trials indicating a patient dropout rate of >15% with recent ADs compared to >20 Inhibitors,research,lifescience,medical % with TCAs, and clinical practice data based on 13 619 prescriptions, which showed dropout rates of 22% and 33%), respectively:4 Inhibitors,research,lifescience,medical Mortality after suicide attempts is almost nonexistent with the newer ADs, while it was between 0.5% and 4%) of patients who were hospitalized after a failed suicide attempt in cases of TCA overdose. Negative aspects of recent antidepressants The adverse drug reactions observed with recent ADs include tremor, nausea, Inhibitors,research,lifescience,medical diarrhea, vertigo, sweating, headache, impaired sexual function, sleep fragmentation, anxiety, nervousness, akathisia (inability to remain in sitting posture, restlessness, muscular quivering, anxiety, irritability), iatrogenic mania, withdrawal symptoms, and the serotonin syndrome. These adverse drug reactions do not occur with all the recent ADs. For example, sedation is typical of nefazodone and mirtazapine, and these ADs also induce dry mouth. Nefazodone does not induce sleep fragmentation, in contrast to the selective serotonin reuptake inhibitors (SSRIs).5 Selleck Fluorouracil Mirtazapine causes weight gain, in contrast to most of the newer ADs like the SSRIs and venlafaxine, which induce Inhibitors,research,lifescience,medical a loss of appetite and an increase in whole body metabolism,

usually resulting in little weight change, although some patients may lose or gain weight because of the treatment. Among the recent ADs, fluoxetine, sertraline, moclobemide, and bupropion are the less sedating molecules, the first two even increase PAK6 choice reaction time in normal volunteers. Sexual adverse reactions, when they occur, are generally a minor problem for the patient during the acute phase of the treatment of a depressive disorder, but they are bothersome during the maintenance phase. The SSRIs (with the possible exception of fluvoxamine) are associated with a higher incidence of sexual dysfunction than nefazodone, moclobemide, or mirtazapine. Bupropion, which influences the dopaminergic system, can activ ate the libido.