A total of 94,119 articles were identified which underwent electronic filtering and manual review. Overall, a dramatic increase in ACHD publications was seen over the study period. This was accompanied by a matching increase in impact factors and an over-proportional rise in ACHD contributions relative to the general academic field.

Research output correlated well with self-reported patient volume and the number of identified ACHD centers in Europe and North America was in agreement with published surveys, thus validating our methodology. We observed a steady increase in the number of publishing ACHD centers world wide. The number of ACHD centers per 10-million population was highest for Europe (3.6), followed by North America (1.7), Oceania (1.5), South America (0.4), Asia (0.3) and Africa (0.1). In addition, we evaluated the relative research buy R788 output between GS-9973 developed and emerging economies and provide an overview over the main areas of research in the ACHD field.\n\nConclusions: Global interest in ACHD is increasing

and this is reflected, both, in the number of publishing centers and the volume of research. Our data provides insights into the geographical and temporal distribution of ACHD research over the last 1 1/2 decades. These results could serve as benchmarks for international comparisons and guide efforts for improving ACHD infrastructure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“In the course find protocol of our investigations on Umutambasha in order to identify its convulsant principles, small quantities of monofluoroacetate were observed in stem bark, leaves, and fruits of this plant newly identified as Dichapetalum michelsonii Hauman. Conclusive evidence

for a monofluoroacetate presence came from its isolation from the freeze-dried extract of stem bark. Three free unusual amino acids, named N-methyl-alpha-alanine, N-methyl-beta-alanine, and 2,7-diaminooctan-1,8-dioic acid, described for the first time in a plant, and known trigonelline were also isolated from the stem bark of D. michelsonii. Structure elucidations were mainly achieved by spectroscopic methods (H-1-NMR, 2D-NMR, MS) and by comparison with authentic references. These unusual amino acids were detected by a fast, reliable TLC analysis in all our batches of Umutambasha, suggesting that they could be used for identification purposes in case of human or livestock intoxications. Finally, EEG recordings and behavioural observations performed in mice suggested that the convulsive patterns produced by Umutambasha are the consequence of monofluoroacetate presence in D. michelsonii.”
“Background: Cardiac structure and function are well-studied in Western countries. However, epidemiological data is still scarce in China.\n\nMethods: Our study was conducted in the framework of cardiovascular health examinations for the current and retired employees of a factory and their family members.