centres Total no selleck screening library Patients buy SCH727965 Patient selection Alcohol consumption inclusion criteria % cirrhosis (significant fibrosis*) Age Yr mean (SD) % male Liver biopsy scoring system Serum marker Recruitment details (where reported Length biopsy/no portal triads Stickel 2003 [23] Germany (1) 87 Admissions for alcohol withdrawal symptoms in current drinkers >100 g alcohol daily 14 (44) n/r n/r Local; Ludwig; Knodell n/r HA Steatosis + mild fibrosis 23% Steatosis + mod fibrosis + inflam 8% Severe fib + inflam 30% Rosenberg 2004 [24] (1998–2000) England (8) Germany Italy Sweden 64 Patients with excess alcohol consumption history and histology Assessed
by each centre 27 44 63 Scheuer ELF panel Ishak (HA TIMP1 PIIINP age) Consecutive prospective recruitment ≥12 mm ≥5 portal tracts Naveau 2005 [25] (1996–2000) France(1) 221 Patients with active history of excess alcohol consumption admitted to hospital (24% decompensated cirrhosis) and with available histology >50 g alcohol daily for 1 year 31(64) 47 77 METAVIR Fibrotest (α2M, apoA1, bilirubin, GGT, haptogloblin, corrected for age + sex) Stage
0 7% Mean length 15 mm ± 05 Stage Nepicastat 1 329% Stage 2 22% Frags = 2.2 ± 0.1 Prospective recruitment Stage 3 11% portal tr 14.4 ± 0.7 HA Stage 4 31% Cales 2005 [26] (1994–2002) France (1) 95 Heavy drinkers with ALD on histology >50 g daily >5 years 41 (80) 49.8 (11.2) 71.6 METAVIR Fibrometer (PT α2M HA) Consecutive prospective recruitment Stage 0 13% Median Length 18.4 ±6.0 Stage 1 18% Stage 2 17% Stage 3 12% Stage 4 41% Lieber 2006 [27] USA (23) 1034: (a) 507 pre-cirrhotic (b) 527 decompensated cirrhosis Patients with heavy alcohol mafosfamide consumption + fibrosis/cirrhosis on biopsy/clinical in 2 treatment RCTs 80 g ethanol daily >5 years HCV negative 51(66) (a) 51 98 Ishak APRI (b) 56 n/r (AST Platelets) Prospective recruitment Study Author: Yr
published (date of study) country No. centres Total no patients Patient selectionrecruitment details (where reported) Alcohol consumption inclusion criteria % cirrhosis (significant fibrosis*) Age Yr mean (SD) % male Liver biopsy scoring system Serum marker Mean length mm/no portal tracts Nguyen –Khac 2008 [28] 103 Patients with attending hepato-GI, alcoholism & Int Med depts. who were HBV- and HCV- without decompensated cirrhosis who agreed to have liver biopsy >50 g daily alcohol for >5 yrs 33 (75) 53 (9.6) 74 METAVIR HA Stage 0 8% length 12.2 ±3 mm Hepascore Stage 1 18% Portal tracts 7.8 ± 2.7 (bilirubin GGT HA age,sex α2M) Stage 2 23% Stage 3 19% PGA Prospective recruitment Stage 4 32% PGAA (PT GGT α2M, apoA1) APRI(AST Pl) Fibrotest Fibrometer *(fibroscan) Lieber 2008 [29] (1994–2000) 247 Heavy alcohol consumption and fibrosis on biopsy ≥80 g daily .