Markers

of successful outcomes may be associated with the ability to ambulate and lack of late wound formation or eventual amputation. However, there continues to be a paucity of literature investigating functional outcomes and patient satisfaction with regard to lower extremity reconstruction in patients with nontraumatic wounds associated with the aforementioned systemic diseases. Patient reported outcomes measures assessing health related quality of life (HRQoL), functionality, and patient satisfaction are frequently studied via validated questionnaires such as the Short Form-36 (SF-36) Palbociclib cell line and Short Form-12 (SF-12).[3] The SF-12 is a generic 12-part questionnaire adapted from the lengthier SF-36. Assessment of function is separated into two general areas: Physical Health (PCS) and Mental MAPK Inhibitor Library cell assay Health (MCS). Analysis of scores compared to the general United States population provides a quantitative and qualitative understanding of postoperative physical function and patient satisfaction with limb salvage. This study examines long-term functional outcomes and patient satisfaction in patients undergoing lower extremity reconstruction. A retrospective review was conducted of all patients who underwent lower extremity free flap reconstruction (FFR) for lower extremity nontraumatic wounds by the senior author (I.D) between 2005 and 2010. Patients included in this study were identified as having multiple medical comorbidities

with chronic wounds that were treated in the wound center. Patients with acute/traumatic wounds were excluded from analysis. Quality of life was evaluated using the Short Form-12 (SF-12) validated survey used widely in research of patient-reported GPX6 outcomes. Surveys were completed via phone interview at a minimum of one year follow-up. In addition to HRQoL, data related to patient age, length of follow up, development of complications, ability to ambulate post-operatively, and wound formation was collected (Tables 1 and 2). Physical (PCS) and mental (MCS) component scale scores were calculated from each completed SF-12

survey according to algorithms published by QualityMetric (Lincoln, Rhode Island).[4] Scoring was norm-based to achieve a mean of 50 and standard deviation of 10, with lesser values indicating a greater degree of disability. Scores above 50 indicated no disability. PCS and MCS scores were analyzed using VassarStats (Poughkeepsie, NY).[5] Means and confidence intervals were calculated for each subgroup. To assess for statistical significance between subgroups, scores were compared using t-tests. An a priori value of P < 0.05 was considered statistically significant. A total of 57 patients (Table 1) who underwent free flap reconstruction (FFR) were included in this study with an average age of 58.2 years (range, 19–86) and an average follow up period of 235.6 weeks (range, 115–461). Comorbidities included diabetes (36%), peripheral arterial disease (PAD, 24.